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To assess the key secondary endpoint of clinical response rate after the remission induction phase at week 14 and 16 (defined as a decrease in PRO-2 of at least 50% and a decrease in the endoscopic Mayo score 1 and a decrease in the total Mayo score 3 points), the proportion of clinical response in the form of a composite endpoint will be compared between the study group in arm C (IFX + UST) and the control group in arm A + B (IFX and UST) using the Pearson chi-square test