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(20) Additionally, the myocardium of knock-out mice for the CKmit and CK-M isoforms is incapable of maintaining the levels of ATP when the animals are submitted to an intense exercise protocol, despite the baseline levels not showing modification

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Hence, PDOXs, within early passages and/or with an established genomic parity with their corresponding primary GBM, represent a more superior model compared to GEMs in the sense that PDOXs more faithfully resemble human GBM