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Description

The problem of cyanocobalamin defeciency in a developing country setup and the possible solutions

This is another reason to use fresh vials and respect storage timelines rather than trying to stretch supplies beyond recommended periods

Neurological Symptoms Deficient serum folate concentrations can lead to neurological symptoms

0 % Of vegetarians may have low B12 levels

Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions